c-Jun N-Terminal Kinase Pathway Activation in Human and Experimental Cerebral Contusion

Role of c-Jun N-terminal kinase in cerebral vasospasm after experimental subarachnoid hemorrhage.

BACKGROUND AND PURPOSE Inflammation could play a role in cerebral vasospasm after subarachnoid hemorrhage (SAH). SP600125 a c-Jun N-terminal kinase (JNK) inhibitor reduces inflammation. The present study examined if SP600125 could reduce cerebral vasospasm. METHODS Twenty-seven dogs were assigned to 5 groups: control, SAH, SAH plus dimethyl sulfoxide (DMSO), SAH plus SP600125 (10 micromol/L),...

Jun N - terminal Kinase - 1 activation

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c-Jun N-terminal kinase mediates constitutive human eosinophil apoptosis.

Eosinophils are considered to play an important role in the pathogenesis of asthma. Glucocorticoids are potent anti-inflammatory agents for the treatment of chronic inflammatory diseases and they have been shown to increase the rate of eosinophil apoptosis. c-Jun N-terminal kinase (JNK) has been suggested to participate in the signaling pathways of apoptosis. The aims of the present study were ...

N-Terminal Kinase Pathway Fibroblast Cells Activates the c-Jun Varicella-Zoster Virus Infection of Human

c-Jun N-Terminal Kinase in Inflammation and Rheumatic Diseases

The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family and are activated by environmental stress. JNK is also activated by proinflammatory cytokines, such as TNF and IL-1, and Toll-like receptor ligands. This pathway, therefore, can act as a critical convergence point in immune system signaling for both adaptive and innate responses. Like other MAP...